Condition
Treatment Support
astringent
Application
tea, tincture
Knotweed
(Polygonum aviculare)
Also know as Knotgrass
Botanical Information
A low-growing inconspicuous annual weedy plant in the Buckwheat family with opposite leaves.
Working with Knotweed
Part(s) Used
Root
Herb Forms
Bulk herb, tincture
Christopher Hobbs;
“This wild plant contains tannins and is used as an astringent for diarrhea and hemorrhage. It is mildly diuretic and is indicated for urinary gravel or stones, kidney or bladder infections, and painful urination. In Chinese medicine knotweed is employed as a diuretic, to regulate urination, and expel worms.
Knotweed has a taste of BITTER, ASTRINGENT and a temperature of COLD.”
Historical Uses
Knotweed (primarily Polygonum cuspidatum, also known as Japanese knotweed) has been used historically in Traditional Chinese Medicine (TCM) and other Asian folk medicines. It was used to treat inflammatory conditions, liver diseases, and cardiovascular ailments, often as a detoxifying herb and anti-inflammatory agent. The plant, particularly its roots, was valued for reducing heat and addressing skin and liver issues.
Modern Clinical Uses by Herbalists and Naturopaths
Today, herbalists and naturopaths use knotweed for its anti-inflammatory, antioxidant, and immune-boosting properties. Knotweed is rich in resveratrol, a compound with cardiovascular and neuroprotective effects, and is often recommended for Lyme disease, arthritis, and chronic inflammatory diseases. It is also sometimes used to support liver health, as it may aid in detoxification.
Chemistry and Pharmacology
Knotweed contains various bioactive compounds, the most well-known being resveratrol, which is a polyphenolic compound also found in red wine. Other active constituents include polydatin, emodin, quercetin, and catechins. These compounds contribute to its antioxidant, antimicrobial, and anti-inflammatory properties, as well as potential cardiovascular and neuroprotective benefits. Resveratrol, in particular, influences cellular processes related to aging, inflammation, and stress resistance.
Clinical trials on knotweed and its primary compound, resveratrol, show promise, particularly in cardiovascular health, neuroprotection, and anti-inflammatory effects. Studies suggest resveratrol can reduce markers of inflammation, improve blood flow, and offer some protection against neurodegenerative diseases. While evidence is growing, more large-scale, controlled trials are needed to confirm efficacy and determine optimal dosages for various conditions.
Generated by Chat GPT; edited by Christopher Hobbs
Cautions
Knotweed is generally considered safe when used in moderate doses, though gastrointestinal discomfort, diarrhea, and mild allergic reactions may occur. The herb should be used with caution in individuals with hormone-sensitive conditions, as some compounds in knotweed may affect hormone levels. Those on anticoagulant therapy should be cautious as knotweed may have blood-thinning effects due to resveratrol. For general health benefits, a lower dose may be effective, while higher doses are sometimes used in Lyme disease protocols under practitioner supervision.
Avoid use of this herb if you have a deficiency condition, such as deficiency of hormones and metabolic substances (Kidney Yin deficiency in Chinese medicine).
Conditions treated with Knotweed
Condition
Treatment Support
Application
Condition
Treatment Support
mild diuretic
Application
tea, tincture
Condition
Treatment Support
diuretic
Application
tea, tincture
The information given here is designed to help you make informed choices about your health. The information is drawn from numerous sources—both traditional medicine practice, from the clinical experience of many herbalists currently practicing, and supported by decades of scientific research from the author. The research most consulted includes human clinical trials that help to determine the most effective and safe herbs for various needs, the best doses, and types of preparations.
The information offered in this database is not intended as a substitute for any that may have been prescribed by your health practitioner or physician.
