Condition
Treatment Support
heat remover
Application
tincture, tea, capsules, tablets
Oregon Grape
(Mahonia aquifolium [=Berberis aquifolium]; M. spp.)
Also know as Oregon grapeholly
Botanical Information
A perennial native plant of the barberry family with stiff prickly leaves, clusters of yellow flowers, and sour bright blue berries.
Working with Oregon Grape
Part(s) Used
Root
Herb Forms
Tincture, capsule, bulk herb, powder
Christopher Hobbs:
“The roots and lower stems of Oregon grape contain the yellow alkaloid berberine, which has broad-spectrum antibiotic activity and has been recently studied for its ability to reduce inflammation in the body, regulate blood sugar, increase insulin sensitivity, and lower cholesterol.
Oregon grape root is associated with the liver and gallbladder, having a cooling, or inflammation-reducing effect on the liver and a regulating action on the bile. Berberine-containing herbs like goldenseal and the Chinese herb huan lian, or coptis, are used worldwide to help relieve inflammatory conditions of the lower abdominal area (especially those associated with the intestines) and liver (which also benefits gallbladder inflammation). Oregon grape root has been recommended for heat in the stomach with such symptoms as tooth and gum pain, inflamed gums, a burning and gnawing feeling in the stomach area, styes, and facial acne. It may also be useful for vaginal yeast infections. Oregon grape root tea, tincture, and other kinds of extracts are especially indicated for skin problems such a dermatitis, eczema, boils, and acne, and they have a beneficial effect on gastric ulcers as well.
Oregon Grape has a taste of BITTER and a temperature of COLD.”
Historical Uses
Traditionally, Oregon grape was used by Native American tribes for various medicinal purposes. Its roots were commonly used as a remedy for digestive problems, infections, and skin conditions. The plant was also utilized for its antimicrobial properties.
Modern Clinical Uses
Herbalists and naturopaths use Oregon grape primarily for its antibacterial, antifungal, and anti-inflammatory properties. It is commonly used in treating skin conditions (like eczema and acne), digestive issues (such as constipation or colitis), and as a tonic for the liver and gallbladder.
Chemistry and Pharmacology
The plant contains several bioactive compounds, such as alkaloids (berberine being the most notable), flavonoids, and saponins. Berberine, in particular, has been studied for its antimicrobial effects and ability to support liver function. Oregon grape is also thought to modulate gut health through its antimicrobial activity.
Clinical Trials
While Oregon grape has not been the subject of a large number of clinical trials, there is research indicating the effectiveness of its active compounds, particularly berberine, in treating conditions like bacterial infections, skin conditions, and metabolic disorders. Some studies have supported its role in improving gut health and liver function, though larger, well-controlled clinical trials are still needed to confirm these benefits conclusively. The evidence for Oregon grape’s effectiveness in treating skin conditions, such as acne, is relatively strong in smaller trials and anecdotal reports, though more robust studies are required.
In summary, Oregon grape has a long history of traditional use and modern clinical applications, especially in treating infections and skin conditions, with promising but still developing evidence from clinical trials.
Generated by ChatGPT; edited by Christopher Hobbs
Cautions
Generally considered safe for short-term use. However, excessive doses of Oregon grape, especially in concentrated forms, may cause side effects such as nausea, diarrhea, or upset stomach. Berberine in large amounts can also cause lower blood sugar levels, which may be problematic for people with diabetes. Pregnant and breastfeeding women should avoid it due to its potential effects on uterine contractions.
For the most part, berberine-containing herbs like Oregon grape root are very safe. Do not exceed the recommended dose or use it for more than 1 or 2 weeks without advice from an herbalist. Berberine can lead to as much as a 50 percent increase in blood levels of some pharmaceuticals.
Conditions treated with Oregon Grape
Condition
Treatment Support
Application
Condition
Treatment Support
heat and toxin clearing
Application
tincture, capsule
Condition
Treatment Support
antibacterial
Application
tincture, capsule
Condition
Treatment Support
clears heat
Application
tincture, capsule
Condition
Treatment Support
liver stimulant
Application
tincture, capsule
Condition
Treatment Support
heat remover
Application
tincture, tea, capsules, tablets
Condition
Treatment Support
heat clearing
Application
tincture
Condition
Treatment Support
liver coolant
Application
tincture, tablet, capsule
The information given here is designed to help you make informed choices about your health. The information is drawn from numerous sources—both traditional medicine practice, from the clinical experience of many herbalists currently practicing, and supported by decades of scientific research from the author. The research most consulted includes human clinical trials that help to determine the most effective and safe herbs for various needs, the best doses, and types of preparations.
The information offered in this database is not intended as a substitute for any that may have been prescribed by your health practitioner or physician.
